New Research Names Gene Responsible for Tumor Formation, Spread: Anton Bilchik MD Explains

New Research Names Gene Responsible for Tumor Formation, Spread: Anton Bilchik MD Explains

As the nation’s leading colorectal cancer surgeon, Anton Bilchik MD knows that inflammation is a key risk factor for cancer – especially colon cancer – but doctors have never been able to understand exactly how inflammation stimulates the development and spread of cancer. New research shows the action of the gene CXCR2, which causes inflammation, changing the body’s circulatory system in a way that feeds cancerous tissue.  Doctors may someday use this knowledge to target therapies that neutralize the effects of CXCR2 on colon cancer.

Colon cancer affects the large intestine in the lower part of your digestive system; when it affects the rectum, doctors refer to it as colorectal cancer. Most cases of colon cancer begin as small clumps of cells, known as polyps. In time, these polyps may turn into cancer. Inflammation increases the risk for colon cancer. For example, 20 percent of people with a type of inflammatory bowel disease develop colon cancer within 30 years of diagnosis. Colorectal cancer is the second leading cancer-related death among men and women in the United States.

In this recent study, researchers removed the CXCR2 from mice and noted that the usual signs of inflammation disappeared, suppressing tumor formation. When scientists injected these test mice with the CXCR2 gene, inflammation and tumor production returned. The study suggests CXCR2 causes inflammation that allows tumor-friendly substances to pass from the circulatory system into the colon.

As a colorectal cancer surgeon, Anton Bilchik MD is dedicated to a deeper understanding of the causes of and treatments for colon cancer. He continues to lead groundbreaking research and implementation of new procedures for treating colorectal cancers.